Outcomes of critically ill solid organ transplant patients with COVID‐19 in the United States. Issue 11 (15th September 2020)

• Record Type: Journal Article
• Authors: Molnar, Miklos Z.; Bhalla, Anshul; Azhar, Ambreen; Tsujita, Makoto; Talwar, Manish; Balaraman, Vasanthi; Sodhi, Amik; Kadaria, Dipen; Eason, James D.; Hayek, Salim S.; Coca, Steven G.; Shaefi, Shahzad; Neyra, Javier A.; Gupta, Shruti; Leaf, David E.; Kovesdy, Csaba P.
• Other Names: Walther Carl P. investigator.; Anumudu Samaya J. investigator.; Arunthamakun Justin investigator.; Kopecky Kathleen F. investigator.; Milligan Gregory P. investigator.; McCullough Peter A. investigator.; Nguyen Thuy‐Duyen investigator.; Shaefi Shahzad investigator.; Krajewski Megan L. investigator.; Shankar Sidharth investigator.; Pannu Ameeka investigator.; Valencia Juan D. investigator.; Waikar Sushrut S. investigator.; Kibbelaar Zoe A. investigator.; Athavale Ambarish M. investigator.; Hart Peter investigator.; Upadhyay Shristi investigator.; Vohra Ishaan investigator.; Oyintayo Ajiboye investigator.; Green Adam investigator.; Rachoin Jean‐Sebastien investigator.; Schorr Christa A. investigator.; Shea Lisa investigator.; Edmonston Daniel L. investigator.; Mosher Christopher L. investigator.; Shehata Alexandre M investigator.; Cohen Zaza investigator.; Allusson Valerie investigator.; Bambrick‐Santoyo Gabriela investigator.; Bhatti Noor ul aain investigator.; Mehta Bijal investigator.; Williams Aquino investigator.; Brenner Samantha K. investigator.; Walters Patricia investigator.; Go Ronaldo C. investigator.; Rose Keith M. investigator.; Hernán Miguel A. investigator.; Lisk Rebecca investigator.; Zhou Amy M. investigator.; Kim Ethan C. investigator.; Chan Lili investigator.; Mathews Kusum S. investigator.; Coca Steven G. investigator.; Altman Deena R. investigator.; Saha Aparna investigator.; Soh Howard investigator.; Wen Huei Hsun investigator.; Bose Sonali investigator.; Leven Emily A. investigator.; Wang Jing G. investigator.; Mosoyan Gohar investigator.; Nadkarni Girish N. investigator.; Pattharanitima Pattharawin investigator.; Gallagher Emily J. investigator.; Friedman Allon N. investigator.; Guirguis John investigator.; Kapoor Rajat investigator.; Meshberger Christopher investigator.; Kelly Katherine J. investigator.; Parikh Chirag R. investigator.; Garibaldi Brian T. investigator.; Corona‐Villalobos Celia P. investigator.; Wen Yumeng investigator.; Menez Steven investigator.; Malik Rubab F. investigator.; Cervantes Carmen Elena investigator.; Gautam Samir C. investigator.; Mallappallil Mary C. investigator.; Ouyang Jie investigator.; John Sabu investigator.; Yap Ernie investigator.; Melaku Yohannes investigator.; Mohamed Ibrahim investigator.; Bajracharya Siddhartha investigator.; Puri Isha investigator.; Thaxton Mariah investigator.; Bhattacharya Jyotsna investigator.; Wagner John investigator.; Boudourakis Leon investigator.; Nguyen H. Bryant investigator.; Ahoubim Afshin investigator.; Kashani Kianoush investigator.; Tehranian Shahrzad investigator.; Thomas Leslie F. investigator.; Sirganagari Dheeraj Reddy investigator.; Guru Pramod K. investigator.; Zhou Yan investigator.; Bergl Paul A. investigator.; Rodriguez Jesus investigator.; Shah Jatan A. investigator.; Gupta Mrigank S. investigator.; Kumar Princy N. investigator.; Lazarous Deepa G. investigator.; Kassaye Seble G. investigator.; Melamed Michal L. investigator.; Johns Tanya S. investigator.; Mocerino Ryan investigator.; Prudhvi Kalyan investigator.; Zhu Denzel investigator.; Levy Rebecca V. investigator.; Azzi Yorg investigator.; Fisher Molly investigator.; Yunes Milagros investigator.; Sedaliu Kaltrina investigator.; Golestaneh Ladan investigator.; Brogan Maureen investigator.; Kumar Neelja investigator.; Chang Michael investigator.; Thakkar Jyotsana investigator.; Raichoudhury Ritesh investigator.; Athreya Akshay investigator.; Farag Mohamed investigator.; Schenck Edward J. investigator.; Cho Soo Jung investigator.; Plataki Maria investigator.; Alvarez‐Mulett Sergio L. investigator.; Gomez‐Escobar Luis G. investigator.; Pan Di investigator.; Lee Stefi investigator.; Krishnan Jamuna investigator.; Whalen William investigator.; Charytan David investigator.; Macina Ashley investigator.; Chaudhry Sobaata investigator.; Wu Benjamin investigator.; Modersitzki Frank investigator.; Srivastava Anand investigator.; Leidner Alexander investigator.; Martinez Carlos investigator.; Kruser Jacqueline M. investigator.; Wunderink Richard G. investigator.; Hodakowski Alexander J. investigator.; Velez Juan Carlos Q. investigator.; Price‐Haywood Eboni G. investigator.; Matute‐Trochez Luis A. investigator.; Hasty Anna E. investigator.; Mohamed Muner MB investigator.; Avasare Rupali S. investigator.; Zonies David investigator.; Leaf David E investigator.; Gupta Shruti investigator.; Sise Meghan E. investigator.; Newman Erik T. investigator.; Omar Samah Abu investigator.; Pokharel Kapil K. investigator.; Sharma Shreyak investigator.; Singh Harkarandeep investigator.; Correa Simon investigator.; Shaukat Tanveer investigator.; Kamal Omer investigator.; Wang Wei investigator.; Yang Heather investigator.; Boateng Jeffery O. investigator.; Lee Meghan investigator.; Strohbehn Ian A. investigator.; Li Jiahua investigator.; Mueller Ariel L. investigator.; Redfern Roberta E. investigator.; Cairl Nicholas S. investigator.; Naimy Gabriel investigator.; Abu‐Saif Abeer investigator.; Hall Danyell investigator.; Bickley Laura investigator.; Rowan Chris investigator.; Madhani‐Lovely Farah investigator.; Peev Vasil investigator.; Reiser Jochen investigator.; Byun John J. investigator.; Vissing Andrew investigator.; Kapania Esha M. investigator.; Post Zoe investigator.; Patel Nilam P. investigator.; Hermes Joy‐Marie investigator.; Sutherland Anne K. investigator.; Patrawalla Amee investigator.; Finkel Diana G. investigator.; Danek Barbara A. investigator.; Arikapudi Sowminya investigator.; Paer Jeffrey M. investigator.; Cangialosi Peter investigator.; Liotta Mark investigator.; Radbel Jared investigator.; Puri Sonika investigator.; Sunderram Jag investigator.; Scharf Matthew T. investigator.; Ahmed Ayesha investigator.; Berim Ilya investigator.; Vatson Jayanth S. investigator.; Anand Shuchi investigator.; Levitt Joseph E. investigator.; Garcia Pablo investigator.; Boyle Suzanne M. investigator.; Song Rui investigator.; Arif Ali investigator.; Zhang Jingjing investigator.; Woo Sang Hoon investigator.; Deng Xiaoying investigator.; Katz‐Greenberg Goni investigator.; Senter Katharine investigator.; Sharshir Moh'd A. investigator.; Rusnak Vadym V investigator.; Ali Muhammad Imran investigator.; Peters Terri investigator.; Hughes Kathy investigator.; Bansal Anip investigator.; Podoll Amber S. investigator.; Chonchol Michel investigator.; Sharma Sunita investigator.; Burnham Ellen L. investigator.; Douin David J. investigator.; Rashidi Arash investigator.; Hejal Rana investigator.; Judd Eric investigator.; Latta Laura investigator.; Tolwani Ashita investigator.; Albertson Timothy E. investigator.; Adams Jason Y. investigator.; Chang Steven Y. investigator.; Beutler Rebecca M. investigator.; Schulze Carl E. investigator.; Macedo Etienne investigator.; Rhee Harin investigator.; Liu Kathleen D. investigator.; Jotwani Vasantha K. investigator.; Koyner Jay L. investigator.; Shah Chintan V. investigator.; Jaikaransingh Vishal investigator.; Toth‐Manikowski Stephanie M. investigator.; Joo Min J. investigator.; Lash James P. investigator.; Neyra Javier A. investigator.; Chaaban Nourhan investigator.; Elias Madona investigator.; Ahmad Yahya investigator.; Iardino Alfredo investigator.; Au Elizabeth H. investigator.; Sharma Jill H. investigator.; Sosa Marie Anne investigator.; Taldone Sabrina investigator.; Contreras Gabriel investigator.; Zerda David De La investigator.; Fornoni Alessia investigator.; Gershengorn Hayley B. investigator.; Hayek Salim S. investigator.; Blakely Pennelope investigator.; Berlin Hanna investigator.; Azam Tariq U. investigator.; Shadid Husam investigator.; Pan Michael investigator.; Hayer Patrick O' investigator.; Meloche Chelsea investigator.; Feroze Rafey investigator.; Kishan J. Padalia investigator.; Bitar Abbas investigator.; Leya Jeff investigator.; Donnelly John P. investigator.; Admon Andrew J. investigator.; Flythe Jennifer E. investigator.; Tugman Matthew J. investigator.; Chang Emily H. investigator.; Brown Brent R. investigator.; Leonberg‐Yoo Amanda K. investigator.; Spiardi Ryan C. investigator.; Miano Todd A. investigator.; Roche Meaghan S. investigator.; Vasquez Charles R. investigator.; Bansal Amar D. investigator.; Ernecoff Natalie C. investigator.; Kapoor Sanjana investigator.; Verma Siddharth investigator.; Chen Huiwen investigator.; Kovesdy Csaba P. investigator.; Molnar Miklos Z. investigator.; Azhar Ambreen investigator.; Hedayati S. Susan investigator.; Nadamuni Mridula V. investigator.; Shastri Shani investigator.; Willett Duwayne L. investigator.; Short Samuel A.P. investigator.; Renaghan Amanda D. investigator.; Enfield Kyle B. investigator.; Bhatraju Pavan K. investigator.; Malik A. Bilal investigator.; Semler Matthew W. investigator.; Vijayan Anitha investigator.; Joy Christina Mariyam investigator.; Li Tingting investigator.; Goldberg Seth investigator.; Kao Patricia F. investigator.; Schumaker Greg L. investigator.; Goyal Nitender investigator.; Faugno Anthony J. investigator.; Hsu Caroline M. investigator.; Tariq Asma investigator.; Meyer Leah investigator.; Kshirsagar Ravi K. investigator.; Jose Aju investigator.; Weiner Daniel E. investigator.; Christov Marta investigator.; Griffiths Jennifer investigator.; Gupta Sanjeev investigator.; Kapoor Aromma investigator.; Wilson Perry investigator.; Arora Tanima investigator.; Ugwuowo Ugochukwu investigator.;
• Is Part Of: American journal of transplantation. Volume 20:Issue 11(2020)
• Page Start: 3061
• Page End: 3071
• Publication Date: 2020-09-15
• Subjects: clinical research/practice -- complication: infectious -- infection and infectious agents ‐ viral -- infectious disease -- kidney transplantation/nephrology -- organ transplantation in general -- patient survival; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16280
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID‐19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory‐confirmed COVID‐19 admitted to intensive care units (ICUs) at 68 hospitals across the United States from March 4 to May 8, 2020. From 4153 patients, we created a propensity score matched cohort of 386 patients, including 98 SOT patients and 288 non‐SOT patients. We used a binomial generalized linear model (log‐binomial model) to examine the association of SOT status with death and other clinical outcomes. Among the 386 patients, the median age was 60 years, 72% were male, and 41% were black. Death within 28 days of ICU admission was similar in SOT and non‐SOT patients (40% and 43%, respectively; relative risk [RR] 0.92; 95% confidence interval [CI]: 0.70‐1.22). Other outcomes and requirement for organ support including receipt of mechanical ventilation, development of acute respiratory distress syndrome, and receipt of vasopressors were also similar between groups. There was a trend toward higher risk of acute kidney injury requiring renal replacement therapy in SOT vs. non‐SOT patients (37% vs. 27%; RR [95% CI]: 1.34 [0.97‐1.85]). Death and organ support requirement were similar between SOT and non‐SOT critically ill patients with COVID‐19. Abstract : Solid organ transplant recipients with critical SARS‐CoV‐2 infection have a similar risk of death, acute respiratory distress syndrome, and requirement for organ support as nonsolid organ transplant patients.