Clinical outcomes and serologic response in solid organ transplant recipients with COVID‐19: A case series from the United States. Issue 11 (17th July 2020)

• Record Type: Journal Article
• Authors: Fung, Monica; Chiu, Charles Y.; DeVoe, Catherine; Doernberg, Sarah B.; Schwartz, Brian S.; Langelier, Charles; Henrich, Timothy J.; Yokoe, Deborah; Davis, John; Hays, Steven R.; Chandran, Sindhu; Kukreja, Jasleen; Ng, Dianna; Prostko, John; Taylor, Russell; Reyes, Kevin; Bainbridge, Emma; Bond, Allison; Chin‐Hong, Peter; Babik, Jennifer M.
• Is Part Of: American journal of transplantation. Volume 20:Issue 11(2020)
• Page Start: 3225
• Page End: 3233
• Publication Date: 2020-07-17
• Subjects: antibody biology -- clinical research/practice -- infection and infectious agents – viral -- infectious disease; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16079
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS coronavirus 2 (SARS‐CoV‐2) has caused significant morbidity and mortality for patients and stressed healthcare systems worldwide. The clinical features, disease course, and serologic response of COVID‐19 among immunosuppressed patients such as solid organ transplant (SOT) recipients, who are at presumed risk for more severe disease, are not well characterized. We describe our institutional experience with COVID‐19 among 10 SOT patients, including the clinical presentation, treatment modalities, and outcomes of 7 renal transplant recipients, 1 liver transplant recipient, 1 heart transplant recipient, and 1 lung transplant recipient. In addition, we report the serologic response in SOT recipients, documenting a positive IgG response in all 7 hospitalized patients. We also review the existing literature on COVID‐19 in SOT recipients to consolidate the current knowledge on COVID‐19 in the SOT population for the transplant community. Abstract : This study reports the clinical course of 10 solid organ transplant recipients with COVID‐19, including positive IgG serologic responses among all hospitalized patients.