Changes in quality of life in patients with low‐flow aortic stenosis undergoing transcatheter aortic valve replacement. Issue 4 (20th February 2020)

• Record Type: Journal Article
• Authors: Ahmed, Aisha; Alsidawi, Said; Bae, Richard; Cavalcante, Joao; Fukui, Miho; Gössl, Mario; Sorajja, Paul; Garcia, Santiago
• Is Part Of: Catheterization and cardiovascular interventions. Volume 96:Issue 4(2020)
• Page Start: 972
• Page End: 978
• Publication Date: 2020-02-20
• Subjects: low flow -- quality of life -- transcatheter aortic valve replacement; Heart -- Diseases -- Diagnosis -- Periodicals; Cardiac catheterization -- Periodicals; 616.1207572
• DOI: 10.1002/ccd.28805
• Languages: English
• ISSNs: 1522-1946

Abstract

Abstract: Background: We sought to quantify and compare changes in quality of life measures after transcatheter aortic valve replacement (TAVR) in patients with low‐flow (LF) and normal‐flow (NF) aortic stenosis (AS). Methods: We included 297 patients treated with TAVR at Abbott Northwestern Hospital from January 2015 to October 2017. Health status was assessed at baseline and 30 days post‐procedure using the Kansas City Cardiomyopathy Questionnaire 12 (KCCQ‐12). Overall (KCCQ‐OS) and domain‐specific (physical limitation, symptom frequency, quality of life, and social limitation) scores were compared in three subsets of patients as defined by stroke volume index (≤ or >35 ml/m 2 ), ejection fraction (EF) (≤ or >40%), and mean gradient (≤ or >40 mmHg). Results: Of the 297 patients included, 129 (43%) had NF high‐gradient (NF AS group) and 168 (56%) had LF severe AS, including 25 (8%) with low EF (8%) ("Classical" low‐flow low‐gradient LEF [LF‐LG‐LEF] group) and 143 (48%) with preserved EF ("Paradoxical" LF‐LG group). At baseline, patients with LF‐LG‐LEF AS had more severe impairment in symptoms frequency ( p = .06) but similar KCCQ‐OS. At 1‐month after TAVR, all groups had moderate improvements in quality of life (Delta KCCQ‐OS: "Classical" LF‐LG‐LEF 18 ± 21, paradoxical AS 14 ± 18, and NF AS 15 ± 16, p = .57). During a median follow‐up time of 2.4 years, there was no difference in mortality ( p = .34) but patients with paradoxical LF‐LG AS had a higher risk of rehospitalization for heart failure ( p = .01). Conclusions: Patients with LF severe AS derive significant improvements in quality of life measures after TAVR, indistinguishable from patients with NF AS.