Computational Large‐Scale Mapping of Protein‐Protein Interactions Using Structural Complexes. Issue 1 (16th February 2018)

• Record Type: Journal Article
• Authors: Shoemaker, Benjamin; Wuchty, Stefan; Panchenko, Anna R.
• Editors: Coligan, John E.; Dunn, Ben M.; Speicher, David W.; Wingfield, Paul T.
• Is Part Of: Current protocols in protein science. Volume 73:Issue 1(2013)
• Page Start: 3.9.1
• Page End: 3.9.9
• Publication Date: 2018-02-16
• Subjects: protein interaction -- structural complex -- binding interface -- IBIS -- Inferred Biomolecular Interactions Server; Proteins -- Laboratory manuals; Proteins; Clinical Laboratory Techniques; Genetic Techniques; Immunologic Techniques; Proteins; Laboratory manuals; 572.6028
• DOI: 10.1002/0471140864.ps0309s73
• Languages: English
• ISSNs: 1934-3655

Abstract

Abstract: Although the identification of protein interactions by high‐throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein‐protein or gene‐gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation. Curr. Protoc. Protein Sci . 73:3.9.1‐3.9.9. © 2013 by John Wiley & Sons, Inc.