RETAINED, NONDISSOLVING, TUBULAR FOREIGN BODIES IN THE VITREOUS CAVITY AFTER INTRAVITREAL DEXAMETHASONE (OZURDEX) IMPLANTATION. Issue 11 (November 2020)

• Record Type: Journal Article
• Authors: Han, Ian C.; Critser, D. Brice; Amram, Alec L.; Folk, James C.
• Is Part Of: Retina. Volume 40:Issue 11(2020)
• Publication Date: 2020-11
• Subjects: uveitis -- corticosteroids -- foreign body -- dexamethasone implant -- intravitreal injection; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002824
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To describe the retention of large, tubular, nondissolving foreign bodies because of a complication of the intravitreal dexamethasone implant (Ozurdex). Methods: This is a single-center, retrospective chart review of patients who were found to have retained, nondissolvable tubular foreign bodies in the vitreous cavity for more than 6 months (the expected dissolution time of the implants) after Ozurdex injections. Ocular symptomatology and multimodal imaging were reviewed. Results: Five patients had retained, nondissolvable tubular foreign bodies in the vitreous that persisted for months (mean 28.2 months, range 9–67 months) after intravitreal injection of Ozurdex. Two patients were symptomatic due to the foreign bodies and chose alternate local therapy, but none of the patients opted for surgical explantation. Conclusion: Persistent, nondissolving, tubular foreign bodies can be seen in the vitreous cavity for years after injection of the Ozurdex implant. Clinicians should be aware of this complication that has the potential to cause visual symptoms and ocular morbidity. Abstract : Supplemental Digital Content is Available in the Text.Intravitreal dexamethasone implant (Ozurdex) is in everyday use for the treatment of diabetic macular edema, cystoid macular edema with retinal vein occlusion, and noninfectious posterior uveitis. In this article, we describe the ocular findings of five patients who had retained, nondissolving, tubular intravitreal foreign bodies after injection of Ozurdex.