Feasibility of 177Lu Therapy Monitoring Using Fast Whole-Body SPECT Recordings Provided by a High-Speed 360° CZT Camera. (November 2020)

• Record Type: Journal Article
• Authors: Chevalier, Elodie; Boursier, Caroline; Claudin, Marine; Marie, Pierre-Yves; Imbert, Laetitia
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 11(2020)
• Publication Date: 2020-11
• Subjects: 177Lu -- absolute quantification -- CZT camera -- neuroendocrine -- PRRT -- SUV; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003169
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: The whole-body absolute quantification of 177 Lu-DOTATATE therapy was achieved using a high-speed 360° CZT SPECT/CT system. Twelve high-resolution swelling detectors may be positioned close to patients, providing a high-count sensitivity that is particularly advantageous for the low-count rate conditions of 177 Lu imaging. After initially validating 177 Lu quantification on phantom, serial whole-body SPECT/CT acquisitions of only 20 minutes were obtained for a 70-year-old woman treated by 177 Lu-DOTATATE injections for a metastatic recurrence of a pancreatic neuroendocrine tumor. The progressive decrease in tumor uptake between the consecutive 177 Lu-DOTATATE injections could be quantified, and thereby the corresponding dosimetry changes could be estimated.