Development and evaluation of safety and effectiveness of novel cancer screening tests for routine clinical use with applications to multicancer detection technologies. (8th February 2022)

• Record Type: Journal Article
• Authors: Doubeni, Chyke A.; Lau, Yan Kwan; Lin, Jennifer S.; Pennello, Gene A.; Carlson, Robert W.
• Is Part Of: Cancer. Volume 128:Supplement 4 (2022)
• Page Start: 883
• Page End: 891
• Publication Date: 2022-02-08
• Subjects: cancer screening -- multicancer early detection -- multicancer screening -- test development framework -- tumor of origin -- standard of care screening test -- clinical reference standard -- diagnostic test accuracy -- clinical utility -- lead time bias; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.33954
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Multicancer screening is a promising approach to improving the detection of preclinical disease, but current technologies have limited ability to identify precursor or early stage lesions, and approaches for developing the evidentiary chain are unclear. Frameworks to enable development and evaluation from discovery through evidence of clinical effectiveness are discussed. Abstract : Multicancer screening is a promising approach to improve the detection of preclinical disease, but current technologies have limited ability to identify precursor or early stage lesions, and approaches for developing the evidentiary chain are unclear. Frameworks to enable development and evaluation from discovery through evidence of clinical effectiveness are discussed.