AUTOPHAGY AND AGING: LESSONS FROM LONG-LIVED C. ELEGANS. (11th November 2018)

• Record Type: Journal Article
• Authors: Hansen, M
• Is Part Of: Innovation in aging. Volume 2(2018)Supplement 1
• Page Start: 387
• Page End: 387
• Publication Date: 2018-11-11
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igy023.1442
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: The cytosolic recycling process of autophagy plays an important role in many age-related diseases and has been directly linked to aging, including in the nematode C. elegans where autophagy appears beneficially induced in many conserved longevity models. As a critical process to ensure cellular homeostasis, autophagy is regulated at multiple levels, yet it remains a challenge in the field to understand how the regulation of autophagy is integrated at the cellular and molecular level to ensure health- and lifespan benefits. I will here discuss our progress on understanding the different molecular mechanisms employed by cells and organisms to regulate autophagy in response to stressors such as aging and disease.