Giant Cell Tumor With Atypical Imaging Implying Osteosarcoma. (November 2020)

• Record Type: Journal Article
• Authors: Ariga, Akane; Kanda, Hiroaki; Ando, Yoshiaki; Gokita, Tabu
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 11(2020)
• Publication Date: 2020-11
• Subjects: antihistone G34W staining -- differential diagnosis -- giant cell tumor of bone -- osteoblastic radiological findings; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003226
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Giant cell tumor (GCT) of bone is benign and typically shows osteolytic changes on x-ray, whereas osteosarcoma is malignant and generally shows osteolytic and osteoblastic mixed images. We experienced a rare case of GCT with atypical radiological findings. The tumor found in the right knee of a 15-year-old girl comprised a wide range of osteoblastic and osteolytic lesion in medial femur. Technetium uptake, however, was detected only in osteoblastic part, and immunohistochemical staining of biopsy showed diffusely positive for antihistone G34W and almost negative for Ki-67. These results strongly suggest the tumor was GCT.