Incidental Detection of Malignant Melanoma Brain Recurrence on 68Ga–Prostate-Specific Membrane Antigen PET/CT. (November 2020)

• Record Type: Journal Article
• Authors: Hod, Nir; Lantsberg, Sophie; Benkovich, Elya; Kazap, Dina Ezroh; Preiskel, Mark; Levin, Daniel
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 11(2020)
• Publication Date: 2020-11
• Subjects: 68Ga-PSMA -- brain tumor -- incidentaloma -- malignant melanoma -- MRI -- PET/CT; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003216
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 76-year-old man with a prior medical history of resected malignant melanoma of the skull underwent 68 Ga–prostate-specific membrane antigen (PSMA) PET/CT due to rising tumor markers of a known prostate carcinoma. Unexpected high 68 Ga-PSMA brain uptake was encountered around the surgical cavity in the skull with initially no specific structural changes on anatomical imaging. Successive CT and MRI eventually revealed local melanoma brain recurrence at this site. This interesting case demonstrates the diagnostic potential of 68 Ga-PSMA PET/CT imaging for detection of malignant melanoma brain recurrence.