18F-THK5351 PET Can Identify Lesions of Acute Traumatic Brain Injury. (November 2020)

• Record Type: Journal Article
• Authors: Takami, Yasukage; Yamamoto, Yuka; Norikane, Takashi; Mitamura, Katsuya; Hatakeyama, Tetsuhiro; Nishiyama, Yoshihiro
• Is Part Of: Clinical nuclear medicine. Volume 45:Number 11(2020)
• Publication Date: 2020-11
• Subjects: 18F-THK5351 -- acute traumatic brain injury -- PET -- primary brain injury; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003165
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: A 67-year-old woman sustained a mild traumatic brain injury (TBI) in a traffic accident and had an initial Glasgow Coma Scale score of 13. She underwent 18 F-THK5351 PET 18 days after TBI. Fused 18 F-THK5351 PET/MRI showed that the location of 18 F-THK5351 accumulations corresponded anatomically to intraparenchymal lesions of acute TBI on MRI. 18 F-THK5351 reportedly binds to monoamine oxidase B highly expressed in astrocytes. Furthermore, TBI induces reactive astrogliosis or blood-brain barrier breakdown included in primary brain injury. Therefore, 18 F-THK5351 uptake may represent primary brain injury in acute TBI lesions.