Are Modic Changes Associated With Health-related Quality of Life After Discectomy: A Study on 620 Patients With Two-year Follow-up. Issue 21 (1st November 2020)

• Record Type: Journal Article
• Authors: Udby, Peter Muhareb; Ohrt-Nissen, Søren; Bendix, Tom; Paulsen, Rune; Støttrup, Christian; Andresen, Andreas; Brorson, Stig; Carreon, Leah Y.; Andersen, Mikkel Østerheden
• Is Part Of: Spine. Volume 45:Issue 21(2020)
• Publication Date: 2020-11-01
• Subjects: back pain -- disc degeneration -- herniated lumbar disc -- LBP -- long-term follow-up -- Modic changes -- spine; Spine -- Abnormalities -- Periodicals; Spine -- Diseases -- Periodicals; Spine -- Surgery -- Periodicals; 616.73005
• DOI: 10.1097/BRS.0000000000003618
• Languages: English
• ISSNs: 0362-2436

Abstract

Abstract : Study Design: A registry-based comparative cohort study with 2-year follow-up. Objective: To assess whether Modic changes (MCs) are associated with health-related quality of life, long-term physical disability, back- or leg pain after discectomy. Summary of Background Data: Previous studies have failed to show a clinically significant association between MCs and patient-reported outcomes (PROs) after discectomy. Methods: Data from the Danish National Spine Registry on patients undergoing first-time lumbar discectomy at a single institution from 2014 to 2017 with an accessible preoperative lumbar magnetic resonance imaging, complete preoperative, and 2-year follow-up questionnaires were obtained. PROs including Oswestry disability index (ODI), European Quality of Life—Five Dimensions (EQ-5D), visual analogue scale (VAS) back and leg pain, and patient satisfaction were collected. Patients were stratified based on the presence (+MC) or absence (−MC) of MCs on the preoperative MRI. Results: Of 620 patients included, MCs were present in 290 patients (47%). Of these, MC type 1 (MC-1) was present in 73 (25%) and MC type 2 (MC-2) in 217 (75%) patients. Preoperative data for ODI, EQ-5D, VAS-BP, and VAS-LP were comparable for the +MC and −MC groups. Both groups had a statistically significant improvement in PROs from baseline compared with 2-year follow-up ( P < 0.001). At 2-year follow-up, both groups had improved with no significant difference between them in regards to ODI (15.5 vs. 17.2, P = 0.208); EQ-5D (0.75 vs. 0.72, P = 0.167); VAS-BP (27.1 vs. 28.3, P = 0.617); VAS-LP (26.8 vs. 25.0, P = 0.446); and patient satisfaction (74% vs. 76%, P = 0.878). Conclusion: MCs were not found to be associated with health-related quality of life, disability, back- or leg pain, or patient satisfaction 2 years after discectomy. Level of Evidence: 2 Abstract : A registry-based cohort study of discectomy patients (n=620) with 2-year follow-up. MCs were present in 290 patients (47%). Preoperative data for ODI, EQ-5D, VAS-BP, and VAS-LP were comparable for the +MC and −MC groups. Both groups had a statistically significant improvement in PROs from baseline compared with 2-year follow-up ( P < 0.001).