Texture Analysis of Hepatocellular Carcinoma on Magnetic Resonance Imaging: Assessment for Performance in Predicting Histopathologic Grade. Issue 6 (November 2020)

• Record Type: Journal Article
• Authors: Choi, Jeong Min; Yu, Jeong-Sik; Cho, Eun-Suk; Kim, Joo Hee; Chung, Jae-Joon
• Is Part Of: Journal of computer assisted tomography. Volume 44:Issue 6(2020)
• Publication Date: 2020-11
• Subjects: texture analysis -- hepatocellular carcinoma -- histopathologic grade -- MRI; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000001087
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: The aim of the study was to evaluate the performance of texture analysis for discriminating the histopathological grade of hepatocellular carcinoma (HCC) on magnetic resonance imaging. Methods: Preoperative magnetic resonance imaging data from 101 patients with HCC, including T2-weighted imaging, arterial phase, and apparent diffusion coefficient mapping, were analyzed using texture analysis software (TexRAD). Differences among the histological groups were analyzed using the Mann-Whitney U test. The performance of texture features was evaluated using receiver operating characteristic analysis. Results: Entropy was the most significantly relevant texture feature for distinguishing each histological grade group of HCC ( P < 0.05). In ROC analysis, entropy with spatial scale filter 3 (area under curve the receiver operating characteristic curve [AUC], 0.778), mean with coarse filter (spatial scale filter 5; AUC, 0.670), and skewness without filtration (AUC, 0.760) had the highest AUC value on T2-weighted imaging, arterial phase, and apparent diffusion coefficient maps, respectively. Conclusions: Magnetic resonance imaging texture analysis demonstrated potential for predicting the histopathological grade of HCCs.