Simultaneous Electrochemical Detection of Estradiol and Testosterone Using Nickel Ferrite Oxide Doped Mesoporous Carbon Nanocomposite Modified Sensor. Issue 8 (20th May 2020)

• Record Type: Journal Article
• Authors: Tanrıkut, Emrullah; Özcan, İmren; Sel, Evren; Köytepe, Süleyman; Savan, Ebru Kuyumcu
• Is Part Of: Journal of the Electrochemical Society. Volume 167:Issue 8(2020)
• Publication Date: 2020-05-20
• Subjects: Estradiol -- Testosterone -- NiFe2O4 Nanoparticles -- Mesoporous Carbon Sensor; Electrochemistry -- Periodicals; 541.3705
• DOI: 10.1149/1945-7111/ab927f
• Languages: English
• ISSNs: 0013-4651

Abstract

Abstract : Estradiol levels in women are related to lung, uterine (endometrial), ovarian and breast cancers, although the exact mechanism of cancer development is not fully understood. A new cost-effective sensor was fabricated by incorporating conductive NiFe2 O4 metal oxide into the electrochemical sensitive platform of mesoporous carbon (MC) derived from cotton to measure estradiol determination by electrochemical methods. A new modified GCE/NiFe2 O4 -MC electrode, which exhibits electrocatalytic activities, was created by dropping NiFe2 O4 -MC onto the glassy carbon electrode (GCE) surface using the drop casting technique to detect the electroactive estradiol molecule. Estradiol was determined electrochemically by using the square wave voltammetry technique with a detection limit of 6.88 nM in 20.0–566 nM linear range in phosphate buffer solution at pH 7.4 with this novel modified GCE/NiFe2 O4 -MC electrode, that has the best electron transfer rate. The simultaneous determination of estradiol in the presence of testosterone was successfully performed in 0.1 M tetrabutylammonium tetrafluoroborate supportive electrolyte solution prepared in acetonitrile, an anhydrous medium. Real sample applications were carried out to prove the applicability and precision of the novelty-produced electrode. The amount of estradiol in tablet samples was obtained satisfactorily with high recovery values by standard addition method.