Dimeric sesquiterpenoid-4H-chromone derivatives from agarwood of Aquilaria crassna and their cytotoxicity. (January 2018)

• Record Type: Journal Article
• Authors: Yang, Yang; Chen, Hui-Qin; Kong, Fan-Dong; Zhou, Li-Man; Li, Wei; Dong, Wen-Hua; Chen, Zhi-Bao; Mei, Wen-Li; Dai, Hao-Fu
• Is Part Of: Phytochemistry. Volume 145(2018)
• Page Start: 207
• Page End: 213
• Publication Date: 2018-01
• Subjects: Aquilaria crassna -- Thymelaeaceae -- Agarwood -- Dimeric compounds -- Cytotoxicity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.08.007
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Six previously undescribed uncommon ester-bonded dimeric compounds (aquilacrassnins A–F) containing a sesquiterpenoid and a 5, 6, 7, 8-tetrahydroxy-2-(2-phenylethyl)-5, 6, 7, 8-tetrahydro -4 H -chromone units were isolated from the EtOAc extract of agarwood originating from Aquilaria crassna . Their structures were elucidated by spectroscopic (NMR, UV, IR, MS, and ECD) methods. All the compounds were tested for AChE inhibitory activity and cytotoxicity against K562, BEL-7402, SGC-7901, Hela, and A549 tumor cell lines. The results showed that aquilacrassnin A, B, and E exhibited weak cytotoxicity against the five tested cell lines, whereas all the compounds were inactive against AChE. Graphical abstract: Phytochemistry investigations on Aquilaria crassna originated agarwood led to the isolation of six previously undescribed dimeric sesquiterpenoid-4 H -chromone derivatives. Image 1 Highlights: Six previously undescribed compounds were isolated from agarwood of Aquilaria crassna . The dimers of sesquiterpenoid-4 H -chromones are a relatively unusual class of chemical components. Aquilacrassnin A, B and E exhibited weak cytotoxicity against the tested cell lines.