Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity. (January 2018)

• Record Type: Journal Article
• Authors: Yan, Shi-Li; Li, Yan-Hong; Chen, Xuan-Qin; Liu, Dan; Chen, Chin-Ho; Li, Rong-Tao
• Is Part Of: Phytochemistry. Volume 145(2018)
• Page Start: 40
• Page End: 47
• Publication Date: 2018-01
• Subjects: Euphorbia neriifolia -- Euphorbiaceae -- Euphorantins S-T -- Euphorneroids A-D -- Anti-HIV activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.10.006
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Six previously undescribed diterpenoids, named euphorantins S–T and euphorneroids A–D, including ingol and ent -atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia . Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent -3-oxoatisan-16 α, 17-acetonide exhibited moderate anti-HIV-1 activities, with EC50 values of 34 μ M (SI = 2.3) and 24 μ M (SI = 1.9), respectively. Graphical abstract: The EtOAc extract of Euphorbia neriifolia exhibited potent anti-HIV activity. Six previously undescribed diterpenoids were isolated from the extract. Two ent -atisane diterpenoids showed moderately active in anti-HIV1. Image 1 Highlights: The EtOAc extract of E. neriifolia exhibited anti-HIV-1 activity from the bioassay screening of 23 plant species extract. Six previously undescribed diterpenoids were isolated from the extract. Two diterpenoids exhibited moderate anti-HIV-1 activity.