Neo-clerodane diterpenoids from the whole plants of Scutellaria formosana. (January 2018)

• Record Type: Journal Article
• Authors: Chen, Xin; Chen, Wenhao; Chen, Guangying; Han, Changri; He, Johnny J.; Zhou, Xueming; Yu, Zhangxin; Dai, Chunyan; Song, Xiaoping
• Is Part Of: Phytochemistry. Volume 145(2018)
• Page Start: 1
• Page End: 9
• Publication Date: 2018-01
• Subjects: Scutellaria formosana -- Labiatae -- Neo-clerodane diterpenoids -- HIV lytic replication; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.09.002
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Scuteformoids A-J, ten previously undescribed neo- clerodane diterpenoids along with one known analogue, were isolated from petroleum ether soluable fraction of the whole plants of Scutellaria formosana . The differences among these compounds are the substituents and stereochemistry at C-13. Their structures were elucidated by 1D and 2D NMR experiments, and the absolute configurations of Scuteformoids A, C, E, F, and I were further confirmed by single-crystal X-ray diffraction. Scuteformoids A, C, D, F, H, and I were evaluated for their inhibitory effects against HIV lytic replication and cytotoxic activities. All of them showed weak anti-HIV activities, with EC50 values ranging from 48.24 to 79.17 μg/mL. Graphical abstract: Image 1 Highlights: Eleven neo- clerodane diterpenoids were isolated from Scutellaria formosana. Their absolute configurations were confirmed by single-crystal X-ray diffraction. Some were evaluated for their inhibitory effects against HIV lytic replication.