Design and fabrication of a non-clogging scaffold composed of semi-permeable membrane. (15th March 2018)

• Record Type: Journal Article
• Authors: Tan, Shiyi; Gu, Jiafei; Han, Seung Chul; Lee, Dong-Weon; Kang, Kiju
• Is Part Of: Materials & design. Volume 142(2018)
• Page Start: 229
• Page End: 239
• Publication Date: 2018-03-15
• Subjects: 3D membrane architecture -- Minimal surface -- Scaffold -- 3D lithography; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2018.01.033
• Languages: English
• ISSNs: 0264-1275

Abstract

Abstract: In this study, a novel concept of polymer scaffold was proposed based on 3D porous membrane architecture. It had two distinct sub-volumes intertwined with each other but separated by a single continuous smooth semi-permeable membrane. One sub-volume was used for cell culture, while the other served as a perfusion channel. Mass transfer was implemented through the interfacial porous membrane. Consequently, this scaffold was expected to be completely free from clogging problem due to growing tissue. The sample scaffolds of poly l -lactic acid (PLLA) was fabricated based on 3D UV photo-lithography and porogen leaching technique, which provided a P-surface-like architecture composed of porous membrane having smooth and fine texture with considerably high porosity. Despite high overall porosity of approximately 97%, these scaffolds had strengths and Young's moduli appropriate for regeneration of bones or cartilages. Wettability and permeability of polydopamine-coated PLLA porous membrane were sufficiently high. Graphical abstract: Unlabelled Image Highlights: A 3D polymer membrane architecture was proposed as a novel concept of bio scaffold. It had two sub-volumes that were intertwined but separated by a semi-permeable membrane. One sub-volume was used for cell culture, while the other served as a perfusion channel. Mass transfer was implemented through the interfacial semi-permeable membrane. Despite very high porosity, its strength & modulus was appropriate for bones or cartilages.