Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects. Issue 6 (December 2017)

• Record Type: Journal Article
• Authors: van Nierop, F. Samuel; Kulik, W.; Endert, Erik; Schaap, Frank G.; Olde Damink, Steven W.; Romijn, Johannes A.; Soeters, Maarten R.
• Is Part Of: Clinical nutrition. Volume 36:Issue 6(2017:Dec.)
• Page Start: 1615
• Page End: 1620
• Publication Date: 2017-12
• Subjects: Bile acids -- FGF19 -- Type 2 diabetes -- Obesity -- Mixed meal test; BA bile acid -- CA cholic acid -- DCA deoxycholic acid -- CDCA chenodexocholic acid; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2016.10.006
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2 diabetes and obesity. In this study we used a 2-week very-low-calorie diet (VLCD) to investigate the effects of weight loss on BA pool composition and postprandial dynamics. Methods: We performed mixed meal tests in obese, insulin resistant subjects before and after the VLCD. We measured postprandial plasma levels of glucose, insulin, BA and the BA-induced enterokine fibroblast growth factor 19 (FGF19). Results: The VLCD decreased weight by 4.5 ± 2.3 kg (p < 0.0001) within 14 days. Weight loss increased peak postprandial deoxycholate (DCA) levels (median [IQR]: 0.90 [0.90] vs. 1.25 [1.35] μmol/L; p = 0.045*). Other BA species, glucose, insulin and FGF19 levels and prandial excursions were not significantly affected. The VLCD decreased resting and postprandial energy expenditure by 7 and 11% respectively. Conclusions: VLCD induced weight loss increased postprandial DCA peak levels and decreased resting energy expenditure in obese insulin resistant subjects.