Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate. (26th February 2022)

• Record Type: Journal Article
• Authors: Lin, Biyue; Kou, Jingping; Xiao, Qingbo; Wu, Shuming; Hu, Ji'an; Li, Jianbing; Zhu, Zhu; Zhou, Xinglin; Xin, Libo; Li, Yanhua; Wang, Zhongqing
• Is Part Of: Tetrahedron. Volume 108(2022)
• Publication Date: 2022-02-26
• Subjects: Vonoprazan fumarate -- Metabolite -- Deuterium-labeled analog -- Synthesis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2022.132669
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A first synthetic research concerning four observed metabolites and their deuterium-labeled analogues of reflux esophagitis drug vonoprazan fumarate is reported. Among which the synthetic methods of three metabolites M − I, M-III, M-IV-Sul, and four stable isotop labeled analogues M-I -d 4, M-II -d 4, M-III -d 4, M-IV-Sul -d 4 have not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy. Graphical abstract: Image 1