EPIGENOMICS AND METABOLOMICS MECHANISMS FOR A GENE X DIET INTERACTION MODULATING AGE-RELATED OBESITY. (11th November 2018)

• Record Type: Journal Article
• Authors: Smith, C; Lai, C; Parnell, L D; Lee, Y; Corella, D; Tucker, K L; Ordovas, J M
• Is Part Of: Innovation in aging. Volume 2(2018)Supplement 1
• Page Start: 408
• Page End: 408
• Publication Date: 2018-11-11
• Subjects: Aging -- Periodicals; Gerontology -- Periodicals; 612.67
• DOI: 10.1093/geroni/igy023.1522
• Languages: English
• ISSNs: 2399-5300

Abstract

Abstract: A functional variant in the apolipoprotein AII (APOA2) gene (rs5082) predisposes homozygous carriers to age-related obesity when habitual saturated fat (SFA) intake is high. We used epigenomics, transcription and metabolomics analyses to identify currently unknown mechanisms underlying this well-replicated gene x diet interaction. We conducted an epigenome-wide scan to compare genetically at-risk to low-risk individuals with low (<22 g/d) or high (≥22 g/d) SFA intake in the Boston Puerto Rican Health Study and validated the findings in the GOLDN Study and the Framingham Heart Study. In these three populations, we identified genotype-dependent differential methylation, only with high SFA intake. Further, metabolomics analysis identified pathways exhibiting genotype-based metabolite differences in the context of high SFA, supporting a relationship between this interaction and appetite and energy intake. These findings provide mechanistic insight into a personalized nutrition approach for reducing obesity risk in older adults.