Development of facial palsy during immunoadsorption plasmapheresis in Miller Fisher syndrome: a clinical report of two cases. Issue 3 (1st March 1998)

• Record Type: Journal Article
• Authors: Chida, Keiji; Takase, Sadao; Itoyama, Yasuto
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 64:Issue 3(1998)
• Page Start: 399
• Page End: 401
• Publication Date: 1998-03-01
• Subjects: Miller Fisher syndrome -- immunoadsorption -- plasmapheresis -- facial palsy; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.64.3.399
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Immunoadsorption plasmapheresis (IAP) using a tryptophan linked gel column has been shown to effectively remove serum IgG anti-GQ1b antibody which may contribute to the pathogenesis of Miller Fisher syndrome. Two patients are reported on with Miller Fisher syndrome, who developed bilateral facial palsy during IAP using a tryptophan column, while ophthalmoplegia, ataxia, and, areflexia were improving. In these patients, the titre of anti-GQ1b antibodies was reduced. The IAP using a tryptophan column has a beneficial effect on Miller Fisher syndrome but may not inhibit the development of facial palsy. The mechanism of such a dissociated effect of IAP on Miller Fisher syndrome is discussed.