Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomised, parallel-group pilot clinical study. Issue 1 (18th January 2022)

• Record Type: Journal Article
• Authors: Raghavan, Kadalraja; Dedeepiya, Vidyasagar Devaprasad; Ikewaki, Nobunao; Sonoda, Tohru; Iwasaki, Masaru; Preethy, Senthilkumar; Abraham, Samuel JK
• Is Part Of: BMJ neurology open. Volume 4:Issue 1(2022)
• Publication Date: 2022-01-18
• Subjects: autism -- neural networks -- behavioural disorder -- paediatric neurology; Neurology -- Periodicals; 616.8
• DOI: 10.1136/bmjno-2021-000203
• Languages: English
• ISSNs: 2632-6140

Abstract

Abstract : Background: Autism spectrum disorders (ASDs) are a wide range of behavioural disabilities for which there are no definite interventional modalities available. Remedial therapies remain the only option but with varying outcomes. We have evaluated the Childhood Autism Rating Scale (CARS) and alpha-synuclein levels in this parallel-group, multiple-arm pilot clinical study after supplementation with a biological response modifier beta-glucan food supplement (Nichi Glucan). Methods: Six subjects with ASD (n=6) Gr. 1 underwent conventional treatment comprising remedial behavioural therapies and L-carnosine 500 mg per day, and 12 subjects (n=12) Gr. 2 underwent supplementation with the Nichi Glucan 0.5 g two times per day along with the conventional treatment. Results: There was a significant decrease in the CARS score in all of the children of the Nichi Glucan Gr.2 compared with the control (p=0.034517). Plasma levels of alpha-synuclein were significantly higher in Gr. 2 (Nichi Glucan) than in the control group Gr. 1 (p=0.091701). Conclusion: Improvement of the behavioural pattern CARS score and a correlating alpha-synuclein level, followed by a safe beta-glucan food supplement, warrants further research on other parameters, such as gut-microbiota evaluation, and relevant neuronal biomarkers which is likely to cast light on novel solutions.