Three-component synthesis of α-indole-β-sulfonyl tetrahydrofurans under metal-free conditions. (12th January 2022)

• Record Type: Journal Article
• Authors: Xu, Haopeng; Pi, Chao; Wu, Yangjie; Cui, Xiuling
• Is Part Of: New journal of chemistry. Volume 46:Number 5(2022)
• Page Start: 2239
• Page End: 2244
• Publication Date: 2022-01-12
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj05749a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : An efficient multi-component reaction has been developed for the synthesis of 2, 3-disubstituted tetrahydrofurans in a "one pot" manner, starting from readily available 2-arylindoles, arylsulfonyl azides, and tetrahydrofuran under simple and easily operated reaction conditions. Abstract : An efficient multi-component reaction has been developed for the synthesis of 2, 3-disubstituted tetrahydrofurans in a "one pot" manner, starting from readily available 2-arylindoles, arylsulfonyl azides, and tetrahydrofuran under simple and easily operated reaction conditions. This process provides a wide array of α-indole-β-sulfonyl tetrahydrofurans in good yields with excellent selectivity, avoiding the use of various additives and transition metals as catalysts.