Insulin resistance and metabolic syndrome criteria in lean, normoglycemic college-age subjects. Issue 5 (September 2018)

• Record Type: Journal Article
• Authors: Townsend, Dana K.; McGregor, Katheryn; Wu, Esther; Cialkowski, Kathryn; Haub, Mark D.; Barstow, Thomas J.
• Is Part Of: Diabetes & metabolic syndrome. Volume 12:Issue 5(2018)
• Page Start: 609
• Page End: 616
• Publication Date: 2018-09
• Subjects: Insulin resistance -- Hyperinsulinemia -- Normoglycemia -- Metabolic syndrome -- College-age; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2018.03.025
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Aims: The goal of this study was to determine insulin sensitivity in a fasted state and during an oral glucose tolerance test (OGTT), in normoglycemic (NGT), lean (L) (n = 35) and, for comparison, overweight/obese (OW/O) (n = 9) college-aged subjects. Materials and Methods: Insulin sensitivity for 44 NGT, normotensive subjects, age 18–26 yrs., was determined by homeostasis model assessment (HOMA-IR) and from Matsuda index (ISI Matsuda). Results: Subjects were normoglycemic fasted (4.59 + 0.35 mmol/L) and at two hours post OGTT (4.52 + 1.35 mmol/L). Besides anthropometric measures, there were significant differences between OW/O and L for fasting insulin ( P < 0.001) and both measures of insulin sensitivity ( P < 0.05). All subjects exhibited a 9-fold range in HOMA-IR (0.88 + 0.51, range 0.3–2.7) and an 8-fold range in ISI Matsuda (11.9 + 4.7, range 3.0–24.2). The latter was inversely correlated with systolic blood pressure ( r = 0.35, P = 0.04) even though subjects were normotensive. In lean subjects, 2.3% were IR by HOMA-IR > 2.1, 5.7% by ISI Matsuda < 5.9, and 22.9% had > one criteria for metabolic syndrome (MetS); 28.6% had some negative metabolic biomarker. Conclusions: Insulin resistance is present in lean, NGT college-age subjects even without MetS criteria and is discernable with an easily applicable OGTT-derived index.