Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development. (December 2018)

• Record Type: Journal Article
• Authors: Kalel, Vishal C; Mäser, Pascal; Sattler, Michael; Erdmann, Ralf; Popowicz, Grzegorz M
• Is Part Of: Current opinion in microbiology. Volume 46(2018)
• Page Start: 116
• Page End: 122
• Publication Date: 2018-12
• Subjects: Microbiology -- Periodicals; 579.05
• DOI: 10.1016/j.mib.2018.11.003
• Languages: English
• ISSNs: 1369-5274

Abstract

Abstract : Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.