Using SomaticSniper to Detect Somatic Single Nucleotide Variants. Issue 1 (21st March 2014)

• Record Type: Journal Article
• Authors: Larson, David E.; Abbott, Travis E.; Wilson, Richard K.
• Editors: Bateman, Alex; Pearson, William R.; Stein, Lincoln D.; Stormo, Gary D.; Yates, John R.
• Is Part Of: Current protocols in bioinformatics. Volume 45:Issue 1(2014)
• Page Start: 15.5.1
• Page End: 15.5.8
• Publication Date: 2014-03-21
• Subjects: next‐generation sequencing -- somatic variant calling -- SomaticSniper; Bioinformatics -- Laboratory manuals; Nucleotide sequence -- Laboratory manuals; Amino acid sequence -- Laboratory manuals; Base Sequence; Amino Acid Sequence; Computational Biology -- methods; Databases, Genetic; Proteins -- analysis; Sequence Analysis -- methods; Sequence Homology; Amino acid sequence; Bioinformatics; Nucleotide sequence; Laboratory Manuals; Laboratory manuals; 570.285
• DOI: 10.1002/0471250953.bi1505s45
• Languages: English
• ISSNs: 1934-3396

Abstract

Abstract: Detecting somatic single nucleotide variants (SNVs) is an essential component of cancer research with next‐generation sequencing data. This unit describes how to run the SomaticSniper somatic SNV detector and then filter the output to eliminate most false positives. It also includes support protocols detailing the compilation of the software. Curr. Protoc. Bioinform . 45:15.5.1‐15.5.8. © 2014 by John Wiley & Sons, Inc.