Parallel Homochiral and Anti‐Parallel Heterochiral Hydrogen‐Bonding Interfaces in Multi‐Helical Abiotic Foldamers. Issue 4 (12th December 2019)

• Record Type: Journal Article
• Authors: Mazzier, Daniela; De, Soumen; Wicher, Barbara; Maurizot, Victor; Huc, Ivan
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 4(2020)
• Page Start: 1606
• Page End: 1610
• Publication Date: 2019-12-12
• Subjects: foldamers -- helix bundles -- molecular design -- structure elucidation -- tertiary structures; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201912805
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A hydrogen‐bonding interface between helical aromatic oligoamide foldamers has been designed to promote the folding of a helix‐turn‐helix motif with a head‐to‐tail arrangement of two helices of opposite handedness. This design complements an earlier helix‐turn‐helix motif with a head‐to‐head arrangement of two helices of identical handedness interface. The two motifs were shown to have comparable stability and were combined in a unimolecular tetra‐helix fold constituting the largest abiotic tertiary structure to date. Abstract : Turn right, then left, left again, and then right : Both P ‐ and M ‐helices can be assembled in the same abiotic tertiary foldamer structures without any control of absolute configurations thanks to the design of P / P, M / M, and P / M helix/helix hydrogen‐bonding interfaces.