Plasmonic Nanoassemblies: Tentacles Beat Satellites for Boosting Broadband NIR Plasmon Coupling Providing a Novel Candidate for SERS and Photothermal Therapy. Issue 10 (30th January 2020)

• Record Type: Journal Article
• Authors: Dey, Priyanka; Tabish, Tanveer A.; Mosca, Sara; Palombo, Francesca; Matousek, Pavel; Stone, Nicholas
• Is Part Of: Small. Volume 16:Issue 10(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-30
• Subjects: branched polymers -- broadband NIR absorbance -- cell toxicity -- core–satellites -- plasmonic nanoassemblies -- surface‐enhanced Raman scattering (SERS); Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201906780
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Optical theranostic applications demand near‐infrared (NIR) localized surface plasmon resonance (LSPR) and maximized electric field at nanosurfaces and nanojunctions, aiding diagnosis via Raman or optoacoustic imaging, and photothermal‐based therapies. To this end, multiple permutations and combinations of plasmonic nanostructures and molecular "glues" or linkers are employed to obtain nanoassemblies, such as nanobranches and core–satellite morphologies. An advanced nanoassembly morphology comprising multiple linear tentacles anchored onto a spherical core is reported here. Importantly, this core‐multi‐tentacle‐nanoassembly (CMT) benefits from numerous plasmonic interactions between multiple 5 nm gold nanoparticles (NPs) forming each tentacle as well as tentacle to core (15 nm) coupling. This results in an intense LSPR across the "biological optical window" of 650−1100 nm. It is shown that the combined interactions are responsible for the broadband LSPR and the intense electric field, otherwise not achievable with core–satellite morphologies. Further the sub 80 nm CMTs boosted NIR‐surface‐enhanced Raman scattering (SERS), with detection of SERS labels at 47 × 10 ‐9 m, as well as lower toxicity to noncancerous cell lines (human fibroblast Wi38) than observed for cancerous cell lines (human breast cancer MCF7), presents itself as an attractive candidate for use as biomedical theranostics agents. Abstract : A distinct core‐multitentacle nanoassembly is developed utilizing small gold nanoparticles (NPs) with limited plasmon resonance in the near‐infrared (NIR). 5 nm NPs assembled as tentacles are attached to 15 nm core using multiarm polymers. They provide an intense broadband absorbance throughout the NIR "optical biological window" over‐and‐above that of a core–satellite. Additionally, a strong surface‐enhanced Raman scattering enhancement makes them potential candidates for optical theranostics.