Frontispiece: Evidence for a Proton‐Coupled Electron Transfer Mechanism in a Biomimetic System for Monoamine Oxidase B Catalysis. Issue 4 (23rd January 2020)

• Record Type: Journal Article
• Authors: Nakamura, Akiko; Latif, Marwa Abdel; Deck, Paul A.; Castagnoli, Neal; Tanko, James M.
• Is Part Of: Chemistry. Volume 26:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-23
• Subjects: deprotonation -- MAO catalysis -- proton-coupled electron transfer -- radical cations -- single-electron transfer; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202080463
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The image shows that single electron transfer is "back on the menu" as a possible mechanism for catalysis by monoamine oxidase B (MAO‐B). By using a chemical model for MAO‐B, a compelling evidence that the initial chemical step of the oxidation of certain tertiary amines involves proton‐coupled electron transfer (PCET) is provided. Molecular oxygen is found to play a key, hitherto unrecognized role in the early steps of the catalysis. The structural/electronic properties of the substrates that provide entry into the electron transfer pathway have been identified and are presented in the Full Paper by J. M. Tanko et al. on page 823 ff.