Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in TALLYHO/JngJ mice. (2nd January 2016)

• Record Type: Journal Article
• Authors: Nascimento, Nara F.; Hicks, Jasmin A.; Carlson, Karen N.; Hatzidis, Aikaterini; Amaral, Danielle N.; Logan, Ryan W.; Seggio, Joseph A.
• Is Part Of: Chronobiology international. Volume 33:Number 1(2016)
• Page Start: 108
• Page End: 116
• Publication Date: 2016-01-02
• Subjects: Advance -- jet-lag -- mouse -- shift-work -- TALLYHO/JngJ -- type-2 diabetes; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.3109/07420528.2015.1108330
• Languages: English
• ISSNs: 0742-0528

Abstract

ABSTRACT: Studies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model –TALLYHO/JngJ – and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.