Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease. (19th February 2016)

• Record Type: Journal Article
• Authors: Galloway-Peña, Jessica; Clement, Meredith E.; Sharma Kuinkel, Batu K.; Ruffin, Felicia; Flores, Anthony R.; Levinson, Howard; Shelburne, Samuel A.; Moore, Zack; Fowler, Vance G.
• Is Part Of: Open forum infectious diseases. Volume 3:Number 1(2016)
• Publication Date: 2016-02-19
• Subjects: group A Streptococcus -- invasive disease -- speB -- Streptococcuspyogenes -- whole-genome sequencing; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofw042
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.