Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus. (12th July 2019)

• Record Type: Journal Article
• Authors: Santiago, Gilberto A; Sharp, Tyler M; Rosenberg, Eli; Sosa Cardona, Iris I; Alvarado, Luisa; Paz-Bailey, Gabriela; Muñoz-Jordán, Jorge L
• Is Part Of: Open forum infectious diseases. Volume 6:Number 7(2019)
• Publication Date: 2019-07-12
• Subjects: antibody-dependent enhancement -- Puerto Rico -- viral load -- Zika virus; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz320
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies. Abstract : Prior dengue virus infection is associated with higher viral load in patients with dengue, but not Zika virus, disease.