Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab. (14th August 2017)

• Record Type: Journal Article
• Authors: Bajema, Kristina L; Simonson, Paul D; Greninger, Alex L; Çoruh, Basak; Pottinger, Paul S; Bhattacharya, Renuka; Liou, Iris W; Jalikis, Florencia G; Fligner, Corinne L; Rakita, Robert M
• Is Part Of: Open forum infectious diseases. Volume 4:Number 3(2017)
• Publication Date: 2017-08-14
• Subjects: acute liver failure -- echovirus -- metagenomic next-generation sequencing -- rituximab; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofx174
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.