Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy. (30th September 2019)

• Record Type: Journal Article
• Authors: Audemard-Verger, Alexandra; Gasnault, Jacques; Faisant, Maxime; Besse, Marie-Catherine; Martin-Silva, Nicolas; Berra, Mado; Fournier, Luc; Boutemy, Jonathan; Maigne, Gwenola; De Boysson, Hubert; Ruet, Alexis; Vabret, Astrid; Chapon, Françoise; Martin-Blondel, Guillaume; Aouba, Achille
• Is Part Of: Open forum infectious diseases. Volume 6:Number 10(2019)
• Publication Date: 2019-09-30
• Subjects: immune checkpoint inhibitor -- JC virus -- nivolumab -- PD-1 -- progressive multifocal leukoencephalopathy; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz374
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1 + macrophages could be the T-cells partnership in immune exhaustion and virus escape. Abstract : PD-1 and its ligand are pivotal in the T-cell-exhaustion pathway involved in viral infections. In this paper, we report a complete response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of brain biopsy suggest that PD-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.