Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia. (1st June 2019)

• Record Type: Journal Article
• Authors: Meumann, Ella M; Anstey, Nicholas M; Currie, Bart J; Piera, Kim A; Baird, Robert; Sarovich, Derek S; Davis, Joshua S
• Is Part Of: Open forum infectious diseases. Volume 6:Number 7(2019)
• Publication Date: 2019-06-01
• Subjects: Acinetobacter baumannii -- community-acquired pneumonia -- recurrence -- relapse -- whole-genome sequencing; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz263
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Community-onset bacteremic Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3–56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.