Sofosbuvir Add-on to Ribavirin Treatment for Chronic Hepatitis E Virus Infection in Solid Organ Transplant Recipients Does Not Result in Sustained Virological Response. (3rd June 2019)

• Record Type: Journal Article
• Authors: van Wezel, E M; de Bruijne, J; Damman, K; Bijmolen, M; van den Berg, A P; Verschuuren, E A M; Ruigrok, G A; Riezebos-Brilman, A; Knoester, M
• Is Part Of: Open forum infectious diseases. Volume 6:Number 8(2019)
• Publication Date: 2019-06-03
• Subjects: chronic hepatitis E -- sofosbuvir -- solid organ transplant recipients; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz346
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Ribavirin is effective for treating immunocompromised patients with chronic hepatitis E virus infection. However, ribavirin treatment is not always successful. We describe 3 solid organ transplant recipients treated with sofosbuvir and ribavirin after failing ribavirin monotherapy. Complete elimination of hepatitis E virus could not be achieved.