One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi. (1st June 2019)

• Record Type: Journal Article
• Authors: Kanyama, Cecilia; Molloy, Síle F; Chan, Adrienne K; Lupiya, Duncan; Chawinga, Chimwemwe; Adams, Jack; Bright, Philip; Lalloo, David G; Heyderman, Robert S; Lortholary, Olivier; Jaffar, Shabbar; Loyse, Angela; van Oosterhout, Joep J; Hosseinipour, Mina C; Harrison, Thomas S
• Is Part Of: Clinical infectious diseases. Volume 70:Number 3(2020)
• Page Start: 521
• Page End: 524
• Publication Date: 2019-06-01
• Subjects: cryptococcal meningitis -- treatment -- long-term follow-up -- Malawi -- HIV; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz454
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).