Effect of Intercurrent Infections and Vaccinations on Immune and Inflammatory Biomarkers Among Human Immunodeficiency Virus-Infected Adults on Suppressive Antiretroviral Therapy. (9th March 2015)

• Record Type: Journal Article
• Authors: Tan, Darrell H. S.; Szadkowski, Leah; Raboud, Janet; Yi, Tae Joon; Shannon, Brett; Kaul, Rupert; Liles, W. Conrad; Walmsley, Sharon
• Is Part Of: Open forum infectious diseases. Volume 2:Number 2(2015)
• Publication Date: 2015-03-09
• Subjects: C-reactive protein -- HIV -- infections -- inflammatory biomarkers -- immune activation -- vaccinations; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv036
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We used generalized estimating equations to quantify the impact of recent vaccination or intercurrent infections on immune and inflammatory biomarkers among 144 human immunodeficiency virus (HIV)-infected adults with HIV RNA < 50 copies/mL on antiretroviral therapy. These events were associated with a 2.244 µg/mL increase in high sensitivity C-reactive protein and should be routinely assessed in future studies.