A Human Immunodeficiency Virus Controller With a Large Population of CD4+CD8+ Double-Positive T Cells. (20th March 2015)

• Record Type: Journal Article
• Authors: Durand, Christine M.; Buckheit, Robert W.; Salgado, Maria; Pohlmeyer, Christopher W.; Walker-Sperling, Victoria E.; Hegarty, Robert W.; Ambinder, Richard F.; Blankson, Joel N.
• Is Part Of: Open forum infectious diseases. Volume 2:Number 2(2015)
• Publication Date: 2015-03-20
• Subjects: AIDS -- double-positive cells -- elite controllers -- HIV -- HIV controllers -- immune activation -- long-term nonprogressors -- viremic controllers; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv039
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4 + CD8 + T cells did not have strong antiviral activity.