Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial. (31st May 2019)

• Record Type: Journal Article
• Authors: Oldenburg, Catherine E; Hinterwirth, Armin; Sié, Ali; Coulibaly, Boubacar; Ouermi, Lucienne; Dah, Clarisse; Tapsoba, Charlemagne; Cummings, Susie L; Zhong, Lina; Chen, Cindi; Sarkar, Samarpita; Bärnighausen, Till; Lietman, Thomas M; Keenan, Jeremy D; Doan, Thuy
• Is Part Of: Clinical infectious diseases. Volume 70:Number 3(2020)
• Page Start: 525
• Page End: 527
• Publication Date: 2019-05-31
• Subjects: resistome -- antimicrobial resistance -- randomized controlled trial; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciz455
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.