Viral Genome Sequencing Proves Nosocomial Transmission of Fatal Varicella. (28th August 2016)

• Record Type: Journal Article
• Authors: Depledge, Daniel P.; Brown, Julianne; Macanovic, Jasna; Underhill, Gill; Breuer, Judith
• Is Part Of: Journal of infectious diseases. Volume 214:Number 9(2016:Nov. 01)
• Page Start: 1399
• Page End: 1402
• Publication Date: 2016-08-28
• Subjects: fatal varicella -- nosocomial transmission -- whole genome sequencing; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiw398
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella-zoster virus with fatal outcome. The index case patient, nursed in source isolation, developed disseminated zoster with rash present for 1 day before being transferred to the intensive care unit (ICU). Two patients who had received renal transplants while inpatients in an adjacent ward developed chickenpox and 1 died; neither patient had direct contact with the index patient.