Foxg1 Regulates the Postnatal Development of Cortical Interneurons. (18th April 2018)

• Record Type: Journal Article
• Authors: Shen, Wei; Ba, Ru; Su, Yan; Ni, Yang; Chen, Dongsheng; Xie, Wei; Pleasure, Samuel J; Zhao, Chunjie
• Is Part Of: Cerebral cortex. Volume 29:Number 4(2019)
• Page Start: 1547
• Page End: 1560
• Publication Date: 2018-04-18
• Subjects: CXCR4 -- Dlx1 -- Foxg1 -- interneuron -- migration; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhy051
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Abnormalities in cortical interneurons are closely associated with neurological diseases. Most patients with Foxg1 syndrome experience seizures, suggesting a possible role of Foxg1 in the cortical interneuron development. Here, by conditional deletion of Foxg1, which was achieved by crossing Foxg1 fl/fl with the Gad2-Cre ER line, we found the postnatal distributions of somatostatin-, calretinin-, and neuropeptide Y-positive interneurons in the cortex were impaired. Further investigations revealed an enhanced dendritic complexity and decreased migration capacity of Foxg1 -deficient interneurons, accompanied by remarkable downregulation of Dlx1 and CXCR4. Overexpression of Dlx1 or knock down its downstream Pak3 rescued the differentiation detects, demonstrated that Foxg1 functioned upstream of Dlx1-Pak3 signal pathway to regulate the postnatal development of cortical interneurons. Due to the imbalanced neural circuit, Foxg1 mutants showed increased seizure susceptibility. These findings will improve our understanding of the postnatal development of interneurons and help to elucidate the mechanisms underlying seizure in patients carrying Foxg1 mutations.