Noninvasive Diagnosis of Infection Using Plasma Next-Generation Sequencing: A Single-Center Experience. (12th July 2019)

• Record Type: Journal Article
• Authors: Rossoff, Jenna; Chaudhury, Sonali; Soneji, Maulin; Patel, Sameer J; Kwon, Soyang; Armstrong, Amy; Muller, William J
• Is Part Of: Open forum infectious diseases. Volume 6:Number 8(2019)
• Publication Date: 2019-07-12
• Subjects: bacterial infection -- metagenomic next-generation sequencing -- viral infection; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz327
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Pediatric patients frequently present with illnesses strongly suggesting infection, but without a clearly identified etiology. Our center has recently added a commercially available plasma metagenomic sequencing assay to its available diagnostic testing. Our experience with the first 100 tests suggests that this technology has good clinical performance with >90% sensitivity.