Characteristics and Outcomes of Pediatric Patients With Ebola Virus Disease Admitted to Treatment Units in Liberia and Sierra Leone: A Retrospective Cohort Study. (25th October 2016)

• Record Type: Journal Article
• Authors: Smit, Michael A.; Michelow, Ian C.; Glavis-Bloom, Justin; Wolfman, Vanessa; Levine, Adam C.
• Is Part Of: Clinical infectious diseases. Volume 64:Number 3(2017)
• Page Start: 243
• Page End: 249
• Publication Date: 2016-10-25
• Subjects: Ebola -- child -- malaria -- mortality -- PCR -- .; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciw725
• Languages: English
• ISSNs: 1058-4838

Abstract

Summary: In a large, retrospective cohort of Ebola virus–infected children aged <18 years, the odds of death were ≥5-fold higher if patients were aged <5 years, had evidence of bleeding, or real-time polymerase chain reaction cycle threshold value ≤20. Abstract: Background: The clinical and virologic characteristics of Ebola virus disease (EVD) in children have not been thoroughly documented. Methods: Consecutive children aged <18 years with real-time polymerase chain reaction (RT-PCR)–confirmed EVD were enrolled retrospectively in 5 Ebola treatment units in Liberia and Sierra Leone in 2014/2015. Data collection and medical management were based on standardized International Medical Corps protocols. We performed descriptive statistics, multivariate logistic regression, and Kaplan-Meier survival analyses. Results: Of 122 children enrolled, the median age was 7 years and one-third were aged <5 years. The female-to-male ratio was 1.3. The most common clinical features at triage and during hospitalization were fever, weakness, anorexia, and diarrhea, although 21% of patients were initially afebrile and 6 patients remained afebrile. Bleeding was rare at presentation (5%) and manifested subsequently in fewer than 50%. The overall case fatality rate was 57%. Factors associated with death in bivariate analyses were age <5 years, bleeding at any time during hospitalization, and high viral load. After adjustment with logistic regression modeling, the odds of death were 14.8-fold higher if patients were aged <5 years, 5-fold higher if the patient had any evidence of bleeding, and 5.2-fold higher if EVD RT-PCR cycle threshold value was ≤20. Plasmodium parasitemia had no impact on EVD outcomes. Conclusions: Age <5 years, bleeding, and high viral loads were poor prognostic indicators of children with EVD. Research to understand mechanisms of these risk factors and the impact of dehydration and electrolyte imbalance will improve health outcomes.