Escherichia coli Dysbiosis Correlates With Gastrointestinal Dysfunction in Children With Cystic Fibrosis. (30th October 2013)

• Record Type: Journal Article
• Authors: Hoffman, Lucas R.; Pope, Christopher E.; Hayden, Hillary S.; Heltshe, Sonya; Levy, Roie; McNamara, Sharon; Jacobs, Michael A.; Rohmer, Laurence; Radey, Matthew; Ramsey, Bonnie W.; Brittnacher, Mitchell J.; Borenstein, Elhanan; Miller, Samuel I.
• Is Part Of: Clinical infectious diseases. Volume 58:Number 3(2014)
• Page Start: 396
• Page End: 399
• Publication Date: 2013-10-30
• Subjects: cystic fibrosis -- microbiota -- Escherichia coli -- inflammation -- malabsorption; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/cit715
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.