Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease. (19th May 2018)

• Record Type: Journal Article
• Authors: Peterson, Tess E; Huppler Hullsiek, Katherine; Wyman Engen, Nicole; Kumarasamy, Nagalingeswaran; Lebech, Anne-Mette; Liappis, Angelike; Papadopoulos, Antonios; Polizzotto, Mark N; Schreiner, Pamela J; Duprez, Daniel; Baker, Jason V
• Is Part Of: Open forum infectious diseases. Volume 5:Number 6(2018)
• Publication Date: 2018-05-19
• Subjects: arterial elasticity -- cardiovascular disease -- HIV infection -- systemic inflammation -- vascular dysfunction; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofy117
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy–naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.