Clofazimine Enteropathy: A Rare and Underrecognized Complication of Mycobacterial Therapy. (2nd September 2016)

• Record Type: Journal Article
• Authors: Szeto, Winnie; Garcia-Buitrago, Monica T.; Abbo, Lilian; Rosenblatt, Joseph D.; Moshiree, Baharak; Morris, Michele I.
• Is Part Of: Open forum infectious diseases. Volume 3:Number 3(2016)
• Publication Date: 2016-09-02
• Subjects: clofazimine -- clofazimine-induced enteropathy -- crystal storing histiocytosis enteropathy -- Mycobacterium abscessus -- petechial hemorrhage; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofw004
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.