Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial. (6th February 2019)

• Record Type: Journal Article
• Authors: Oldenburg, Catherine E; Sié, Ali; Coulibaly, Boubacar; Ouermi, Lucienne; Dah, Clarisse; Tapsoba, Charlemagne; Bärnighausen, Till; Lebas, Elodie; Arzika, Ahmed M; Cummings, Susie; Zhong, Lina; Lietman, Thomas M; Keenan, Jeremy D; Doan, Thuy
• Is Part Of: Open forum infectious diseases. Volume 6:Number 3(2019)
• Publication Date: 2019-02-06
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofz061
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Cohabiting children may share components of their intestinal microbiome. We evaluated whether receipt of azithromycin in one sibling confers changes to the intestinal microbiome in an untreated sibling compared with placebo in a randomized controlled trial. We found no evidence of an indirect effect of antibiotic use in cohabiting children. Clinical Trials Registrations: NCT03187834.