ID Learning Unit—Diagnostics Update: Current Laboratory Methods for Rapid Pathogen Identification in Patients With Bloodstream Infections. (12th November 2015)

• Record Type: Journal Article
• Authors: Rubach, Matthew P.; Hanson, Kimberly E.
• Is Part Of: Open forum infectious diseases. Volume 2:Number 4(2015)
• Publication Date: 2015-11-12
• Subjects: bacteremia -- bloodstream infection -- rapid diagnostics -- septicemia; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofv174
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Diagnostic assays that rapidly identify bloodstream pathogens have the potential to improve patient outcomes and antibiotic stewardship efforts. Current tests are based on the detection of nucleic acids that are specific to a targeted pathogen or based on organism identification using mass spectrometry. Most rapid assays require a positive blood culture as their sample input and expedite pathogen identification by 24–72 hours. For those assays that also report detection of drug resistance markers, information on antimicrobial resistance is expedited by 48–96 hours. This learning unit reviews the basic principles of rapid microorganism identification assays for bloodstream infections with the aim of assisting clinicians in the interpretation and optimal utilization of test results.